Characteristic tension thresholds for opening of different mechanosensitive (MS) channels

Range ~10 MscL: 5 MscS: 1 MscM mN/meter
Organism Unspecified
Reference Haswell ES, Phillips R, Rees DC. Mechanosensitive channels: what can they do and how do they do it? Structure. 2011 Oct 12 19(10):1356-69. p.1358 left column bottom paragraphPubMed ID22000509
Primary Source Kung C, Martinac B, Sukharev S. Mechanosensitive channels in microbes. Annu Rev Microbiol. 2010 64: 313-29.PubMed ID20825352
Comments MscL=Mechanosensitive channel of Large conductance. MscS=Mechanosensitive channel of Small conductance. MscM=the mini-conductance channel. Different MS channels have characteristic tension thresholds for opening, with MscL, MscS, and MscM requiring ~10, 5, and 1 mN m-1 (primary source), respectively, perhaps allowing a graded response in cells to imposed tension gradients.
Entered by Uri M
ID 107622