Number of type I collagen (most abundant human protein) monomers in adult

Value >=1E+21 Monomers/adult
Organism Human Homo sapiens
Reference Di Lullo GA, Sweeney SM, Korkko J, Ala-Kokko L, San Antonio JD. Mapping the ligand-binding sites and disease-associated mutations on the most abundant protein in the human, type I collagen. J Biol Chem. 2002 Feb 8 277(6):4223-31 p.4223 right column 3rd paragraphPubMed ID11704682
Comments "If one considers that protein comprises roughly 20% of body mass (Brozek, J., Grande, F., Anderson, J. T., and Keys, A. (1963) Ann. N. Y. Acad. of Sci. 110, 113–140) and that 30% or more of total protein is represented by collagen (Lehninger, A. L. (1975) Biochemistry, 2nd Ed., p. 135, Worth Publishers, Inc., New York AND Hall, D. A. (ed) (1964) International Review of Connective Tissue Research, Vol. 2, p. 244, Academic Press, New York), and if it is assumed that type I collagen comprises at least 90% of total collagen, it can be calculated that an adult of 70 kg may contain more than 1?10^21 type I collagen monomers."
Entered by Uri M
ID 106944