| Value |
100000
Molecules/cell
Range: Table - link Molecules/cell
|
| Organism |
Human Homo sapiens |
| Reference |
Mark D. Biggin, Animal Transcription Networks as Highly Connected, Quantitative Continua, Developmental cell Volume 21, Issue 4, 18 October 2011, Pages 611-626 DOI 10.1016/j.devcel.2011.09.008 p.617 table 1PubMed ID22014521
|
| Primary Source |
van Steensel B et al., Localization of the glucocorticoid receptor in discrete clusters in the cell nucleus. J Cell Sci. 1995 Sep108 ( Pt 9):3003-11.PubMed ID8537440
|
| Method |
(primary source abstract:) "Immunofluorescent labeling and confocal microscopy" |
| Comments |
"A survey of all credible published estimates that [Biggin] could find for four well studied species suggests that most animal transcription factors are expressed at 10,000–300,000 molecules per nucleus (Table 1). These estimates are further supported by [his] own experience and that of many other biochemists who have purified additional endogenous transcription factors with similar yields to the proteins in Table 1." "The data in Table 1 may be biased toward easily studied proteins, so the identification of transcription factors expressed at lower levels may identify better candidates for Coselective DNA Binding-based regulation." |
| Entered by |
Uri M |
| ID |
106906 |