Decay rates of transcription-related mRNAs and non-transcription related mRNAs in hepatocellular carcinoma cell line HepG2

Range 0.221 h^-1 transcription-related transcripts: 0.127h^-1 nontranscriptional transcripts Hours^-1
Organism Human Homo sapiens
Reference Yang E, van Nimwegen E, Zavolan M, Rajewsky N, Schroeder M, Magnasco M, Darnell JE Jr. Decay rates of human mRNAs: correlation with functional characteristics and sequence attributes. Genome Res. 2003 Aug13(8):1863-72. doi:10.1101/gr.1272403 p.1864 right column 2nd paragraphPubMed ID12902380
Method To study the rates of mRNA degradation (“decay”) in human cells, researchers measured changes in mRNA levels following application of the RNA polymerase inhibitor Actinomycin D with Affymetrix U95Av2 high-density oligonucleotide arrays.
Entered by Uri M
ID 106870