Fraction of cellular proteins that have a covalently bound phosphate
| Value | 30 % |
|---|---|
| Organism | Human Homo sapiens |
| Reference | Cohen P. The regulation of protein function by multisite phosphorylationa 25 year update. Trends Biochem Sci. 2000 Dec25(12):596-601. p.596 left column bottom paragraphPubMed ID11116185 |
| Comments | P.596 left column bottom paragraph: "Approximately 30% of cellular proteins contain covalently bound phosphate, and abnormal levels of protein phosphorylation are a cause or consequence of major diseases such as cancer, diabetes and rheumatoid arthritis. Modulators of this process are being used for the treatment of disease, and many of the drugs that will be developed over the next century are likely to be compounds that target protein kinases and phosphatases [ref 2]." |
| Entered by | Uri M |
| ID | 106841 |