Life time of p53

Value 15 Min
Organism Eukaryotes
Reference Weinberg RA. The retinoblastoma protein and cell cycle control. Cell. 1995 May 5 81(3):323-30. p.326 left column 3rd paragraphPubMed ID7736585
Comments P.326 left column 3rd paragraph: "p53 acts as an intermediary here. Normally a highly unstable protein with a lifetime of 15 min or so, its steady-state levels increase rapidly upon DNA damage, p53 in turn activates expression of the p21 CDKI, and p21 then blocks the activity of both CDK2 and CDK4/CDK6 (Kastan et al., 1991 Hall et al., 1993). As with the other antiproliferative signals, this mechanism prevents phosphorylation of pRB and passage through the R point gate."
Entered by Uri M
ID 106237