Percentage of long term self renewing hematopoietic stem cells (LT-HSC) that are in the cell cycle (ie. not in G0) at any given time

Value 25 %
Organism Mouse Mus musculus
Reference Cheshier SH, Morrison SJ, Liao X, Weissman IL. In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells. Proc Natl Acad Sci U S A. 1999 Mar 16 96(6):3120-5 p.3121 left column 2nd paragraphPubMed ID10077647
Method Study of BrdUrd incorporation (Bromodeoxyuridine) kinetics
Comments P.3121 left column 2nd paragraph: "At any one time, ≈25% of LT-HSC were either in G1 or S/G2/M phases of the cell cycle. Consistent with this, a high proportion of LT-HSC expressed cyclin D2 mRNA. [Investigators] present a model describing the LT-HSC cell cycle kinetics."
Entered by Paul Jorgensen
ID 105229