Table - link
|Itzkovitz S, Tlusty T, Alon U. Coding limits on the number of transcription factors. BMC Genomics. 2006 Sep 19 7: 239.PubMed ID16984633
|Researchers used the superfamily database (version
1.69) to obtain the numbers of TFs from each superfamily
in different organisms. Position-Specific Score Matrices (PSSM) for 46 E. coli transcription
factors, were constructed based on the RegulonDB
database . To measure the similarity between binding sequences of a
pair of factors researchers assessed the distances between their
PSSMs. Measurement of similarity of biological function of TFs. Assessment of the number of possible sequences.
|Transcription factor proteins bind specific DNA sequences to control the expression of genes. They contain DNA binding domains which belong to several super-families, each with a specific mechanism of DNA binding. The total number of transcription factors encoded in a genome increases with the number of genes in the genome. Here, researchers examined the number of transcription factors from each super-family in diverse organisms. The present study suggests that there are
upper bounds on the number of transcription factors
from different super-families. It seems that the more constrained
the binding mechanism, the lower the bound.
The present bounds may be understood in terms of an
optimal coding strategy, in which misrecognition errors