Effective Human Population Size according to Human Leukocyte Antigen system (HLA) interallelic data

Value 10000 Individuals
Organism Human Homo sapiens
Reference Hawks J, Hunley K, Lee SH, Wolpoff M. Population bottlenecks and Pleistocene human evolution. Mol Biol Evol. 2000 Jan17(1):2-22. Table - link PubMed ID10666702
Primary Source Takahata N, Satta Y. Footprints of intragenic recombination at HLA loci. Immunogenetics. 1998 May47(6):430-41.PubMed ID9553149
Method (Primary source) To evaluate the effect of balancing selection and intragenic recombination (or gene conversion) at six individual HLA loci, synonymous nucleotide diversity in different exon groups is examined within (pi w) and between (pi b) allelic lineages that may be defined by either serological or DNA sequence differences.
Comments Table gives the effective population size (Ne) for various nuclear systems. Ne is the number of individuals in an ideally behaving, random- mating population that has the same magnitude of genetic drift as the actual population of interest (Wright 1938 Crow and Kimura 1970 Hartl and Clark 1997). Its calculation always assumes that the genes concerned are neutral and unlinked to genes that may be perturbed by selection (Caballero 1994).
Entered by Uri M
ID 104620