Effective Human Population Size according to beta globin nuclear genetic data

Value 10000 Individuals
Organism Human Homo sapiens
Reference Hawks J, Hunley K, Lee SH, Wolpoff M. Population bottlenecks and Pleistocene human evolution. Mol Biol Evol. 2000 Jan17(1):2-22. Table - link PubMed ID10666702
Primary Source HARDING, R. M. et al, 1997. Archaic African and Asian lineages in the genetic ancestry of modern humans. Am. J. Hum. Genet. 60:722–789.PubMed ID9106523
Method (Primary source) A 3-kb region encompassing the beta-globin gene has been analyzed for allelic sequence polymorphism in nine populations from Africa, Asia, and Europe. A unique gene tree was constructed from 326 sequences of 349 in the total sample.
Comments Table gives the effective population size (Ne) for various nuclear systems. Ne is the number of individuals in an ideally behaving, random- mating population that has the same magnitude of genetic drift as the actual population of interest (Wright 1938 Crow and Kimura 1970 Hartl and Clark 1997). Its calculation always assumes that the genes concerned are neutral and unlinked to genes that may be perturbed by selection (Caballero 1994).
Entered by Uri M
ID 104619