Median half-life of mRNAs by functional class of gene products in four wild-type strains

Range Table - link
Organism Bacteria Escherichia coli
Reference Bernstein JA, Lin PH, Cohen SN, Lin-Chao S. Global analysis of Escherichia coli RNA degradosome function using DNA microarrays. Proc Natl Acad Sci U S A. 2004 Mar 2 101(9):2758-63PubMed ID14981237
Method To investigate the degradosome's proposed role as an RNA decay machine, researchers used DNA microarrays to globally assess alterations in the steady-state abundance and decay of 4,289 E. coli mRNAs at single-gene resolution in bacteria carrying mutations in the degradosome constituents RNase E, polynucleotide phosphorylase, RhlB helicase, and enolase.
Comments Median mRNA half-lives were determined for each functional class (as annotated in Riley, ref. 1) in strains K10, N3433, SH3208 and MG1655. Categories were then ranked from 1 to 16, from lowest to highest stability in each strain.
Entered by Uri M
ID 104323