Mutation rate of HIV reverse transcriptase in cells

Value 3E-05 mutations per bp per cycle
Organism HIV
Reference Mansky LM, Temin HM. Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptase. J Virol. 1995 Aug69(8):5087-94.PubMed ID7541846
Method Mutations in lacZ gene delivered by HIV shuttle vector
Comments For value of 8.5×10^-5 mutations per bp per cycle see O'Neil et al., 2002 PMID 12151398 p.38059 table 1
Entered by Alex Sigal
ID 100606