Range: ±1.7 Table - link hours
||Human Homo sapiens
||Kumei Y, Nakajima T, Sato A, Kamata N, Enomoto S. Reduction of G1 phase duration and enhancement of c-myc gene expression in HeLa cells at hypergravity. J Cell Sci. 1989 Jun93 ( Pt 2):221-6. p.224 table 2PubMed ID2693468
||Abstract: "HeLa cells were grown in monolayer in culture flasks that were centrifuged to generate a constant 18, 35 or 70 g at 37 degrees C for up to 4 days. The cell proliferation was enhanced at 18, 35 and 70 g, most notably at 35 g. Cell cycle analyses with [3H]thymidine (TdR)-colcemid treatment showed that the cell generation time in the 35 g culture was reduced by 17% as compared to the control, which was attributed to a 26% reduction of the G1 phase duration."
||P.223 right column 2nd paragraph: "[Researchers] investigated the cell cycle progression of HeLa cells in the 35 g culture by estimating the duration of each cell cycle phase. No significant differences in the duration of the S, G2 or M phase were observed between the 35 g culture and the control (Table 2). However, the duration of the G1 phase was 5.6 ± 0.6 h in the 35 g culture, as compared to 7.6 ± 0.8 h in the control. The cell generation
time in the 35 g culture was 13.4 ± 1.3 h, as compared to 16.2 ± 1.7 h in the control. Thus the cell cycle progression of HeLa cells was accelerated at 35 g due to reduction of the G1 phase duration. This reduction of the G1 phase duration predominated the enhancement of HeLa cell proliferation at 35 g." For doubling time of 26 hours see Shi 2005 PMID 16222248, supplementary notes p. 4. For doubling time of 20±2 hours see Puck 1956 PMID 13286432 p.278. For doubling time of other human cancerous cell lines see BNID 100685, 103994, 105219