pH and electrical potential in eight cellular compartments

Range Table - link
Organism Human Homo sapiens
Reference H. S. Haraldsdottir, I. Thiele, & R. M. T. Fleming, Quantitative assignment of reaction directionality in a multicompartmental human metabolic reconstruction. Biophys J. 2012 Apr 18 102(8):1703-11. doi: 10.1016/j.bpj.2012.02.032. Supplementary material p.13/27 Table S1PubMed ID22768925
Primary Source See refs beneath table
Method p.1709 right column bottom paragraph:"[Researchers] have calculated in vivo standard transformed Gibbs energy estimates for 1,891 metabolites, 807 transport reactions and 1,322 nontransport reactions in Recon 1, a multicompartmental reconstruction of human metabolism (ref 25). This was accomplished through use of von Bertalanffy 1.1 (ref 22), an open source software package for thermodynamic calculations and reaction directionality assignment in multicompartmental genome scale models."
Comments Supplementary material p.16/27 bottom paragraph continued to p.17/27 top paragraph: "Electrical potential differences across compartmental membranes affect the thermodynamics of ion transport between compartments. As metabolites transported into or out of cellular compartments usually pass through the cytosol [researchers] define the electrical potential across each compartment's membrane (?fcompartment) relative to the cytosol so that ?fcompartment = fcompartment - fcytosol. Membrane potentials in the eight compartments included in Recon 1 are listed in Table S1, and the relevant literature is reviewed in the following sections. As with pH [researchers] assume that no electrical potential difference exists between the cytosol and nucleus." See note above table
Entered by Uri M
ID 107521