Mutation rate per genome per replication

Value 0.0038 mutation/genome/replication Range: Table - link mutation/genome/replication
Organism Bacteriophage Lambda
Reference Drake JW, Charlesworth B, Charlesworth D, Crow JF. Rates of spontaneous mutation. Genetics. 1998 Apr148(4):1667-86. p.1670 table 4PubMed ID9560386
Method Product of 7.7?10-8 (BNID 100220) and genome size (BNID 105770)
Comments "Mutation rates in DNA-based microbes: Rates of spontaneous mutation in this class of organisms were last surveyed in Drake (1991) and are summarized in Table 4 using a few updated values for genome sizes. Unlike the experimental and theoretical limits to the accuracy of the RNA-virus values, the DNA-microbe values were determined in well-studied systems using robust calculations, and the individual values are likely to be accurate to within two-fold. Table 4 shows that µb and G vary inversely and smoothly over nearly four orders of magnitude while µg remains constant. Given the paucity of general, constant values in evolutionary processes, this particular constant is strikingly robust." For description of parameters see link Notice that this is per genome replication not per sexual generation
Entered by Ron Milo - Admin
ID 100222