One of largest known viral genomes

Value 1181.4 kb Range: Table - link kb
Organism Acanthamoeba polyphaga Mimivirus
Reference Claverie JM, Ogata H, Audic S, Abergel C, Suhre K, Fournier PE. Mimivirus and the emerging concept of "giant" virus. Virus Res. 2006 Apr117(1):133-44. doi:10.1016/j.virusres.2006.01.008 p.134 table 1PubMed ID16469402
Primary Source Raoult D, Audic S, Robert C, Abergel C, Renesto P, Ogata H, La Scola B, Suzan M, Claverie JM. The 1.2-megabase genome sequence of Mimivirus. Science. 2004 Nov 19 306(5700):1344-50PubMed ID15486256
Comments "The recently discovered Acanthamoeba polyphaga Mimivirus is the largest known DNA virus. Its particle size (750 nm), genome length (1.2 million bp) and large gene repertoire (911 protein coding genes) blur the established boundaries between viruses and parasitic cellular organisms." 1,181,404 bp according to primary source. Of the ORFs there are protein coding genes previously not found in viruses such as amino-acyl transfer RNA synthetases. This genome is over twice the size of next-largest virus, Bacillus phage G with 497.5kb. See table link. There are at least 27 known cellular genomes smaller than this. See table 2 in Reference. See Abergel et al., 2007 PMID 17855524, p.12406 left column top paragraph:"Acanthamoeba polyphaga mimivirus is the largest known DNA virus. Its particle size (750 nm), genome length (1.2 million bp), and large gene repertoire (>910 protein-coding genes) blur the established boundaries between viruses and parasitic cellular organisms (primary source)."
Entered by Uri M
ID 105142