Molecular mass of (intact) ribosome

Value 2700 kDalton
Organism Bacteria Escherichia coli
Reference Yamamoto T, Izumi S, Gekko K. Mass spectrometry of hydrogen/deuterium exchange in 70S ribosomal proteins from E. coli. FEBS Lett. 2006 Jun 26 580(15):3638-42 p.3638 left column, top and 2nd paragraphPubMed ID16753153
Method "[Researchers] have for the first time successfully analyzed the flexibility of 70S ribosomal proteins in solution by detecting the hydrogen/deuterium exchange with mass spectrometry."
Comments "The ribosome from Escherichia coli, which plays a central role in the peptide synthesis in cells, is a supermacro complex (MW: 2.7 MDa) comprising three RNA molecules and more than 50 proteins. These ribosomal proteins are widely distributed on three RNA molecules by non-covalent intermolecular interactions such as hydrophobic and electrostatic interactions."
Entered by Ron Milo, Paul Jorgensen, Mike Springer
ID 100118