Drop in translation elongation rate as generation time increases

Range from 16aa/sec at generation time 20min to 9aa/sec at generation time 20hours aa/sec
Organism Bacteria Escherichia coli
Reference Sørensen MA, Fehler AO & Svenningsen SL. Transfer RNA instability as a stress response in Escherichia coli: Rapid dynamics of the tRNA pool as a function of demand. RNA Biol. 2017 Oct 12: 0. doi: 10.1080/15476286.2017.1391440 p.14 bottom paragraphPubMed ID29023189
Primary Source [89] Dai X et al., Reduction of translating ribosomes enables Escherichia coli to maintain elongation rates during slow growth. Nat Microbiol. 2016 Dec 12 2: 16231. doi: 10.1038/nmicrobiol.2016.231PubMed ID27941827
Comments P.14 bottom paragraph: "A recent publication from the laboratories of T. Hwa and collaborators show convincingly that the translation elongation rate is kept remarkably constant over a wide range of growth rates, and drops less than two-fold in E. coli (from 16 aa/s to 9 aa/s) when the steady-state generation time is increased by 60 fold (from 20 min to 20 hours) [primary source]. The authors present compelling evidence that the maintenance of a high translation elongation rate is enabled by a reduction in the fraction of actively translating ribosomes during slow growth [primary source]."
Entered by Uri M
ID 114271