Average amount of zinc in human body and level of free intracellular zinc in rat

Range in human body ~1.5-2.5g: free intracellular zinc in rat ≥0.5nM
Organism Mammals
Reference Valko M et al., Redox- and non-redox-metal-induced formation of free radicals and their role in human disease. Arch Toxicol. 2016 Jan90(1):1-37. doi: 10.1007/s00204-015-1579-5 p.25 left column top paragraphPubMed ID26343967
Primary Source Chasapis CT, Loutsidou AC, Spiliopoulou CA, Stefanidou ME (2012) Zinc and human health: an update. Arch Toxicol 86: 521–534. doi:10.1007/s00204-011-0775-1 AND Benters J, Flögel U, Schäfer T, Leibfritz D, Hechtenberg S, Beyersmann D (1997) Study of the interactions of cadmium and zinc ions with cellular calcium homoeostasis using 19F-NMR spectroscopy. Biochem J 15: 793–799PubMed ID22071549, 9148751
Comments P.25 left column top paragraph: "Zinc is one of the most important trace elements found in all body tissues and secretions in relatively high concentrations. The average amount of zinc in the adult body is approximately 1.5–2.5 g. About 85–90 % of total body zinc is found in skeletal muscle and bone, 8–10 % in the skin and the liver and the rest of the zinc in other tissues (primary source Chasapis et al. 2012). The level of free intracellular zinc is as low as 0.5 nM as it was estimated from zinc specific 19F NMR signal of a fluorinated metal probe (primary source Benters et al. 1997). The most common and most stable oxidation state of zinc is +2 [Zn(II)]. Compounds containing zinc(I) are rare and require bulky ligands to stabilize the low oxidation state."
Entered by Uri M
ID 114084