Range |
tRNAs ~3,000,000: ribosomes 300,000: mRNAs ~60,000 1/generation
|
Organism |
Budding yeast Saccharomyces cerevisiae |
Reference |
Phizicky EM, Hopper AK. tRNA biology charges to the front. Genes Dev. 2010 Sep 1 24(17):1832-60. doi: 10.1101/gad.1956510 p.1832 right column top paragraphPubMed ID20810645
|
Primary Source |
Ares M Jr, Grate L, Pauling MH. 1999. A handful of intron-containing genes produces the lion's share of yeast mRNA. RNA 5: 1138–1139 AND Waldron C, Lacroute F. 1975. Effect of growth rate on the amounts of ribosomal and transfer ribonucleic acids in yeast. J Bacteriol 122: 855–865PubMed ID10496214, 1097403
|
Method |
Primary source Waldron et al. abstract: "The RNA from cells growing in different media was analyzed by polyacrylamide gel electrophoresis." |
Comments |
P.1832 right column top paragraph: "tRNA and rRNA genes are highly transcribed, leading to the production in yeast of ∼3 million tRNAs per generation and 300,000 ribosomes (primary source Waldron and Lacroute 1975), compared with about 60,000 mRNAs (primary source Ares et al. 1999). Because of the energy devoted to tRNA and rRNA transcription, and because of the required coordination of tRNA and ribosome function, tRNA transcription via RNA polymerase III (Pol III) and rRNA transcription via Pol I need to be coordinated and regulated in response to cellular nutrient availability and other environmental information." |
Entered by |
Uri M |
ID |
113860 |