Fraction of total membrane lipids that constitute its components

Range cholesterol ~30-40%: sphingolipid ~10-20% %
Organism Mammals
Reference Singh P. Budding Yeast: An Ideal Backdrop for In vivo Lipid Biochemistry. Front Cell Dev Biol. 2017 Jan 10 4 :156. doi: 10.3389/fcell.2016.00156. p.3 left column 2nd paragraphPubMed ID28119915
Primary Source Lange, Y., Swaisgood, M. H., Ramos, B. V., and Steck, T. L. (1989). Plasma membranes contain half the phospholipid and 90% of the cholesterol and sphingomyelin in cultured human fibroblasts. J. Biol. Chem. 264, 3786–3793. AND van Meer, G. (1989). Lipid traffic in animal cells. Annu. Rev. Cell Biol. 5, 247–275. doi: 10.1146/annurev.cb.05.110189.001335PubMed ID2917977, 2688705
Comments P.3 left column 2nd paragraph: "Plasma membrane in mammalian cell usually contains, ~30–40% cholesterol and ~10–20% sphingolipid of total plasma membrane lipids (primary sources). Budding yeast does not have cholesterol and sphingomyelin instead contains inositol phosphoceramide (IPC) and ergosterol, an equivalent of mammalian sphingolipid and cholesterol (Montefusco et al., 2013, 2014, Aguilera-Romero et al., 2014)."
Entered by Uri M
ID 113404