Number of isoforms of neurexin that can be generated by alternative splicing

Range >1,000 Isoforms
Organism Mammals
Reference O'Rourke NA, Weiler NC, Micheva KD, Smith SJ. Deep molecular diversity of mammalian synapses: why it matters and how to measure it. Nat Rev Neurosci. 2012 May 10 13(6):365-79. doi: 10.1038/nrn3170. p.371 left column bottom paragraphPubMed ID22573027
Primary Source Ullrich, B., Ushkaryov, Y. A. & Sudhof, T. C. Cartography of neurexins: more than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neurons. Neuron 14, 497–507 (1995).PubMed ID7695896
Comments p.371 left column bottom paragraph: "Clearly, a vast number of proteins would be needed to encode all the circuits in the brain. Two classes of synaptic adhesion proteins, the neurexins and protocadherins (PCDHs), have large numbers of isoforms and are present both during the initial formation of synaptic connections and in mature synapses. Vertebrates have three neurexin genes, each with two promoters that can drive transcription of a large α-neurexin and smaller β-neurexin [refs 95, 96](reviewed in Ref. 83). Alternative splicing can generate over 1,000 neurexin isoforms, which are expressed in regionally distinct but overlapping brain regions [primary source]." Primary source abstract:"The splicing pattern is conserved in rat and cow."
Entered by Uri M
ID 112021