Ribosome components from the three domains of life

Range Table - link
Organism Various
Reference Poehlsgaard J, Douthwaite S. The bacterial ribosome as a target for antibiotics. Nat Rev Microbiol. 2005 Nov3(11):870-81. p.871 table 1PubMed ID16261170
Comments p.871 left column top paragraph:"As in other fields of molecular biology, Escherichia coli became the standard model for ribosome studies, with useful supplementary information derived from other bacteria and yeast. An overview of the components in ribosomes from the different domains of life is given in TABLE 1." Caption to table:"Ribosomes from all domains of life function in essentially the same manner. Bacterial and archaeal ribosomes are approximately the same size, whereas the ribosomes in Eukarya are much larger. Differences in rRNA and r-protein components allow antibiotics and cytotoxins to exhibit specificity for the ribosomes of one domain. Chloroplast ribosomes (not shown) are structurally closest to the bacterial domain. Mitochondrial ribosomes (based on the rat genome sequence) have evolved away from the other structures, including their cytoplasmic counterparts, and contain a larger complement of r-proteins relative to the rRNA."
Entered by Uri M
ID 111935