Number of nuclear pore complexes (npc)

Range vertebrate cell nucleus ~2,000: yeast cell nucleus ~200 NPC/cell nucleus
Organism Eukaryotes
Reference Adam SA. The nuclear pore complex. Genome Biol. 2001 2(9):REVIEWS0007. p.1 left column bottom paragraphPubMed ID11574060
Comments "Nuclear pore complexes are proteinaceous structures embedded in the double membrane of the nuclear envelope. In order to understand how the NPC functions, it is useful to examine the similarities and differences between NPCs from the yeast Saccharomyces cerevisiae and the frog Xenopus laevis. The NPC is a large structure with a molecular weight of approximately 125 MDa in vertebrates and 66 MDa in yeast [BNID 111129]. A vertebrate cell nucleus contains on the order of 2,000 NPCs, whereas the smaller yeast nucleus contains approximately 200. NPCs have eight-fold rotational symmetry through the central axis of the pore and two-fold mirror symmetry through the plane of the nuclear envelope, suggesting assembly as a modular structure, a notion that is supported by structural and biochemical analysis of pore complex assembly in vitro [refs 3,4]."
Entered by Uri M
ID 111130