Elongation speed of mRNA during the stringent response

Range 19 – 28 nts/s
Organism Bacteria Escherichia coli
Reference Klumpp S, Hwa T. Growth-rate-dependent partitioning of RNA polymerases in bacteria. Proc Natl Acad Sci U S A. 2008 Dec 23 105(51):20245-50. doi: 10.1073/pnas.0804953105. p.20249 right column 2nd paragraphPubMed ID19073937
Primary Source Vogel U, Sorensen M, Pedersen S, Jensen KF, Kilstrup M (1992) Decreasing transcription elongation rate in Escherichia-Coli exposed to amino-acid starvation. Mol Microbiol 6:2191–2200. & Vogel U, Jensen KF (1995) Effects of the antiterminator boxA on transcription elongation kinetics and ppGpp inhibition of transcription elongation in Escherichia coli. J Biol Chem 270 :18335–18340.PubMed ID1406259, 7629155
Comments "The elongation speed of mRNA is reduced to 19–28 nt/s during the stringent response, most likely because of increased RNAP pausing induced by ppGpp (primary sources)."
Entered by Uri M
ID 110067