Percent of genes that Rap1p transcription activator activates

Range ~5 % of genes
Organism Budding yeast Saccharomyces cerevisiae
Reference Bregman A, Avraham-Kelbert M, Barkai O, Duek L, Guterman A, Choder M. Promoter elements regulate cytoplasmic mRNA decay. Cell. 2011 Dec 23 147(7):1473-83. doi: 10.1016/j.cell.2011.12.005. p.1473 right column bottom paragraphPubMed ID22196725
Comments "...a small cis-acting element consisting of two Rap1p-binding sites is required and sufficient to destabilize the transcript. Rap1p is a well-known transcription activator of highly transcribed genes (~5% of the yeast genes). [Researchers] found that depletion of Rap1p leads to the stabilization of mRNAs whose synthesis is activated by this protein. Thus, Rap1p plays a dual role in maintaining the level of specific mRNAs."
Entered by Uri M
ID 110028