Direct sequencing estimates of mutation rates (point mutations)

Range 3.5e-09 - 5.8e-9 Table - link mutations/site/generation
Organism Fruit fly Drosophila melanogaster
Reference Kondrashov FA, Kondrashov AS. Measurements of spontaneous rates of mutations in the recent past and the near future. Philos Trans R Soc Lond B Biol Sci. 2010 Apr 27 365(1544):1169-76. doi: 10.1098/rstb.2009.0286. p.1172 table 1PubMed ID20308091
Primary Source Keightley, P. D., Trivedi, U., Thomson, M., Oliver, F., Kumar, S. & Blaxter, M. L. 2009 Analysis of the genome sequences of three Drosophila melanogaster spontaneous mutation accumulation lines. Genome Res. 19, 1195–1201. (doi:10.1101/gr.091231.109)PubMed ID19439516
Method "As far as quantitative estimates of mutation rate are concerned, a large fraction of them have been obtained in recent studies that use a multigeneration direct sequencing approach (table 1)."
Comments See "comments" column.
Entered by Uri M
ID 109991