Electrical potential di fferences across the inner mitochondrial membrane

Range -155 mV
Organism Rat Rattus norvegicus
Reference H. S. Haraldsdottir, I. Thiele, & R. M. T. Fleming, Quantitative Assignment of Reaction Directionality in a Multicompartmental Human Metabolic Reconstruction, Biophysical J, February 17, 2012, supporting online material p.17/27 2nd paragraphPubMed ID22768925
Primary Source 20) Cortese JD. Rat liver GTP-binding proteins mediate changes in mitochondrial membrane potential and organelle fusion. Am J Physiol. 1999 Mar276(3 Pt 1):C611-20. (21) Hoek, J. B., D. G. Nicholls, and J. R. Williamson, 1980. Determination of the mitochondrial protonmotive force in isolated hepatocytes. J. Biol. Chem. 255:1458-1464. (22) Nobes CD, Brown GC, Olive PN, Brand MD. Non-ohmic proton conductance of the mitochondrial inner membrane in hepatocytes. J Biol Chem. 1990 Aug 5 265(22):12903-9.PubMed ID10069988, 7354039, 2376579
Method measurements made in intact rat hepatocytes using the cationic fluorophore TPMP+.
Comments Three similarly designed studies reported ??m values of -155.2±5.2 mV (20), -161±2.6 mV (21) and -150±1.0 mV (22). Researchers used an intermediate value of -155 mV for ??m.
Entered by Uri M
ID 108125