Natural half-time of spontaneous decarboxylation of Orotidine 5'-monophosphate (OMP) in neutral solution at 25°C

Value 7.8e+7 Years Range: Figure link - link Years
Organism Unspecified
Reference Wolfenden R, Snider MJ. The depth of chemical time and the power of enzymes as catalysts. Acc Chem Res. 2001 Dec34(12):938-45. p.940 right column 3rd paragraph and p.941 fig.4PubMed ID11747411
Primary Source Radzicka A, Wolfenden R. A proficient enzyme. Science. 1995 Jan 6 267(5194):90-3.PubMed ID7809611
Method (primary source abstract:) Reactions in quartz tubes at elevated temperatures.
Comments The last step in pyrimidine biosynthesis is the decarboxylation of orotidine 5'-phosphate to form UMP. The rate of the spontaneous reaction, modeled with 1-methylorotic acid, is 2.8?10^-16 s-1 at 25 °C, corresponding to a half-time of 78 million years (primary source)
Entered by Uri M
ID 107206