Percent of the genomes of humans in Eurasia derived from Neandertals

Range 1-4 %
Organism Human Homo sapiens
Reference Green RE et al, A draft sequence of the Neandertal genome. Science. 2010 May 7 328(5979):710-22.PubMed ID20448178
Method Researchers measured the difference in the percent matching by a statistic D(H1, H2, Neandertal, chimpanzee) (SOM Text 15) that does not differ significantly from zero when the derived alleles in the Neandertal match alleles in the two humans equally often. If D is positive, Neandertal alleles match alleles in the second human (H2) more often, while if D is negative, Neandertal alleles match alleles in the first human (H1)more often. They performed this test using eight present-day humans: two European Americans (CEU), two East Asians (ASN), and four West Africans (YRI), for whom sequences have been generated with Sanger technology, with reads of ~750 bp that they mapped along with the Neandertal reads to the chimpanzee genome. To obtain an independent estimate of the proportion of Neandertal ancestry of non-Africans (f), researchers fit a population genetic model to the D statistics in Table 4 and SOM Text 15 as well as to other summary statistics of the data. Assuming that gene flow from Neandertals occurred between 50,000 and 80,000 years ago, this method estimates f to be between 1 and 4%, consistent with the above estimate (SOM Text 19)
Entered by Uri M
ID 105415