Dimensions of Insulin Growth Factor-I

Range 5.1X3.5X2.2 nm
Organism Human Homo sapiens
Reference Nauman JV, Campbell PG, Lanni F, Anderson JL. Diffusion of insulin-like growth factor-I and ribonuclease through fibrin gels. Biophys J. 2007 Jun 1592(12):4444-50.PubMed ID17400703
Primary Source Vajdos FF, Ultsch M, Schaffer ML, Deshayes KD, Liu J, Skelton NJ, de Vos AM. Crystal structure of human insulin-like growth factor-1: detergent binding inhibits binding protein interactions. Biochemistry. 2001 Sep 1840(37):11022-9PubMed ID11551198
Method Using crystallographic coordinates for IGF-I (Protein Data Bank accession number 1imx (29)) and RasMol software (30), external dimensions of the molecule were estimated by rotating the space-filling structure to orientations showing the maximum and minimum projected widths, then selecting pairs of atoms to obtain outer dimensions. By this procedure, major axes of 51.16, 34.52, and 21.47 Å were determined.
Comments The IGF monomer consists of a globular domain with two small diametrically opposed projections which define the long axis. The external dimensions of the globular domain only were taken as 31.28, 34.52, and 21.47 Å.
Entered by Uri M
ID 104033