||Mayr NA, Yuh WT, Taoka T, Wang JZ, Wu DH, Montebello JF, Meeks SL, Paulino AC, Magnotta VA, Adli M, Sorosky JI, Knopp MV, Buatti JM. Serial therapy-induced changes in tumor shape in cervical cancer and their impact on assessing tumor volume and treatment response. AJR Am J Roentgenol. 2006 Jul187(1):65-72PubMed ID16794157
||Serial MRI examinations (T1-weighted and T2-weighted images) were performed in 60 patients (age range, 29-75 years mean, 53.3 years) with advanced cervical cancer (stages IB2-IVB/recurrent) who were treated with RT at four time points: start of RT, during RT (at 2-2.5 and at 4-5 weeks of RT), and post-RT. Tumor configuration was classified qualitatively into oval, lobulated, and complex based on MR film review.Two methods of volume calculation for each of the 60 patients at the four different time points were analyzed and correlated: the reference standard method of diameter-based calculation and the Region Of Interest-based 3D volumetry method, including the entire tumor region identified and traced on the Magnetic Resonance workstation on all T2-weighted sagittal imaging slices throughout the tumor.