Selection coefficient of cell hosting lambda plasmid

Value 3 Percent
Organism Bacteria Escherichia coli
Reference Hartl DL, Dykhuizen DE. The population genetics of Escherichia coli. Annu Rev Genet. 198418: pp. 53PubMed ID6099090
Primary Source Lin L, Bitner R, Edlin G. Increased reproductive fitness of Escherichia coli lambda lysogens. J Virol. 1977 Feb21(2):554-9.PubMed ID319255
Method Tetrazolium dye assay.
Comments cell hosting lambda plasmid has selective advantage over non-hosting cell. Based on a tetrazolium dye assay, the increased fitness of the lambda lysogen during aerobic growth seems to result from a continued high metabolic rate as glucose becomes limiting, whereas the metabolic rate of the nonlysogen declines.
Entered by Uri M
ID 102554