Nucleotide substitution rate

Range 0.1-1 substitution per genome per cycle
Organism HIV
Reference Wain-Hobson S. Viral burden in AIDS. Nature. 1993 Nov 4366(6450):22.PubMed ID8232532
Primary Source Pathak VK, Temin HM. Broad spectrum of in vivo forward mutations, hypermutations, and mutational hotspots in a retroviral shuttle vector after a single replication cycle: substitutions, frameshifts, and hypermutations. Proc Natl Acad Sci U S A. 1990 Aug87(16):6019-23.PubMed ID2201018
Entered by Uri M
ID 102376