Number of NADH produced per ATP produced

Range in acetate fermentation 1 to 1: in respiration 2.5 to 1 NADH per ATP
Organism Bacteria Escherichia coli
Reference Szenk M, Dill KA, de Graff AMR. Why Do Fast-Growing Bacteria Enter Overflow Metabolism? Testing the Membrane Real Estate Hypothesis. Cell Syst. 2017 Aug 235(2):95-104. doi: 10.1016/j.cels.2017.06.005. p.101 left column bottom paragraph & right column top paragraphPubMed ID28755958
Comments P.101 left column bottom paragraph: "Now, suppose instead that the cell begins to use acetate fermentation when respiration becomes membrane limited, diverting glucose away from the TCA cycle where much of the NADH is made. As a result, acetate fermentation produces fewer NADH per ATP than respiration does, 1-to-1 compared to 2.5-to-1 (Box 1 and Table S1C). The onset of fermentation thus allows the cell to avoid NADH imbalance while generating the ATP necessary to fuel high growth rates (bottom-right cartoon and blue curve in Figure 3)."
Entered by Uri M
ID 114728