Fraction of thymines in DNA that are replaced by the unusual base, 5-hydroxymethyluracil (HOMedU)

Range 16 – 28 % of the thymines
Organism Dinoflagellates
Reference Soyer-Gobillard MO, Dolan MF. Chromosomes of Protists: The crucible of evolution. Int Microbiol. 2015 Dec18(4):209-16. doi: 10.2436/20.1501.01.252 p.212 right column top paragraphPubMed ID27611673
Primary Source [15] Herzog M, Soyer MO (1983) The native structure of dinoflagellate chromosomes and their stabilization by Ca2+ and Mg2+ cations. Eur J Cell Biol 30: 3 [24] Rae PM. 5-Hydroxymethyluracil in the DNA of a dinoflagellate. Proc Natl Acad Sci U S A. 1973 Apr70(4):1141-5.PubMed ID6682763, 4515611
Comments P.212 left column bottom paragraph: "At the molecular level, dinoflagellate DNA is peculiar in terms of density and thermal denaturation due to the presence of an unusual base, 5-hydroxymethyluracil (HOMedU), which replaces 16–28% of the thymines [primary sources]. The occurrence of this pyrimidine base replacing thymine was described for the first time in a bacteriophage [ref 17]."
Entered by Uri M
ID 114600