Apparent second order rate constants for reaction of selected biological oxidants with the amino acid cysteine in different environments at neutral pH (∼7.4) and ∼22°C

Range Table - link M^-1×sec^-1
Organism Generic
Reference Davies MJ. Protein oxidation and peroxidation. Biochem J. 2016 Apr 1 473(7):805-25. doi: 10.1042/BJ20151227 p.807 table 5PubMed ID27026395
Primary Source See refs beneath table
Comments P.806 right column top paragraph: "Reactivity is also critically dependent on the environment of the oxidant and target, this is illustrated in Table 5, which provides rate constants for a number of oxidants with the same amino acid (Cys) in different environments–from free amino acid to the active site of specific enzymes. These data vary by ∼10^8 as a result of environmental and structural factors that make some Cys residues particularly reactive (e.g. in peroxiredoxins) compared with other proteins, the Cys-containing tripeptide glutathione GSH, and the free amino acid [primary sources 4–6]."
Entered by Uri M
ID 114482