Volume of mammalian cell nucleus is larger than yeast nucleus or bacterial cell

Range ~1,000 fold
Organism Various
Reference Bell JC, Kowalczykowski SC. RecA: Regulation and Mechanism of a Molecular Search Engine. Trends Biochem Sci. 2016 Jun41(6):491-507. doi: 10.1016/j.tibs.2016.04.002 p.504 2nd paragraphPubMed ID27156117
Primary Source [58] J. Miné-Hattab, R. Rothstein, Increased chromosome mobility facilitates homology search during recombination, Nat. Cell Biol., 14 (2012), pp. 510–517 doi: 10.1038/ncb2472 [59] V. Dion, et al. Increased mobility of double-strand breaks requires Mec1, Rad9 and the homologous recombination machinery, Nat. Cell Biol., 14 (2012), pp. 502–509 doi: 10.1038/ncb2465 [96] J. Miné-Hattab, R. Rothstein, DNA in motion during double-strand break repair, Trends Cell Biol., 23 (2013), pp. 529–536 doi: 10.1016/j.tcb.2013.05.006PubMed ID22484485, 22484486, 23867212
Comments P.504 2nd paragraph: "Although only 12, 13, or 17 nucleotides are required to define a unique sequence in the E. coli, Saccharomyces cerevisiae, and human genomes, respectively [ref 94], mammalian cells have nuclear volumes approximately 1000 times greater than a yeast nucleus or a bacterial cell [primary sources]."
Entered by Uri M
ID 114126