Volume of pronucleus

Range in 1-cell stage embryo 8.24 ± 0.19: in blastocysts 0.69 ± 0.02 pL
Organism Mouse Mus musculus
Reference Tsichlaki E, FitzHarris G, Nucleus downscaling in mouse embryos is regulated by cooperative developmental and geometric programs. Sci Rep. 2016 Jun 20 6: 28040. doi: 10.1038/srep28040 p.2 top paragraphPubMed ID27320842
Method Abstract: "Here [investigators] use live and fixed imaging, micromanipulation approaches, and small molecule analyses during preimplantation mouse development to probe the mechanisms by which nucleus size is determined."
Comments P.2 top paragraph: "By examining embryos of each developmental stage [investigators] found that nucleus volume decreases ten-fold over the course of preimplantation development, from 8.24 ± 0.19 pL for the male pronucleus in 1-cell stage embryos, to 0.69 ± 0.02 pL for nuclei in blastocysts (Fig. 1B). Therefore, as expected, nucleus size progressively scales down during preimplantation development in mouse."
Entered by Uri M
ID 114012