Period of cycle of metabolic oscillator

Range 3 - 25 most with periods of 12 hours
Organism Budding yeast Saccharomyces cerevisiae
Reference Papagiannakis A, Niebel B, Wit EC, Heinemann M. Autonomous Metabolic Oscillations Robustly Gate the Early and Late Cell Cycle. Mol Cell. 2017 Jan 19 65(2):285-295. doi: 10.1016/j.molcel.2016.11.018. Supplemental Information p.9 figure S3D and p.10 caption to figure S3DPubMed ID27989441
Method Abstract: "Using microfluidics, cell-cycle reporters, and single-cell metabolite measurements, [investigators] found that metabolism of budding yeast is a CDK-independent oscillator that oscillates across different growth conditions, both in synchrony with and also in the absence of the cell cycle. Using environmental perturbations and dynamic single-protein depletion experiments, [they] found that the metabolic oscillator and the cell cycle form a system of coupled oscillators, with the metabolic oscillator separately gating and maintaining synchrony with the early and late cell cycle."
Comments Supplemental Information p.10 caption to figure S3D: "(D) Histogram of the frequency distribution of the periods of 63 metabolic oscillations without budding from 14 cells growing on low glucose and exhibiting multiple subsequent oscillations without budding. The period of each oscillation was estimated from the time between two consecutive troughs. This data shows that the autonomous metabolic oscillator can cycle at broadly different periods ranging from 3 to 25 hours with periods of 12 hours occurring most frequently in cells without cell cycle on low glucose."
Entered by Uri M
ID 113259