Fraction of lipids in stratum corneum (SC) that are ceramides

Range 30-40 %
Organism Unspecified
Reference Proksch E, Brandner JM, Jensen JM. The skin: an indispensable barrier. Exp Dermatol. 2008 Dec17(12):1063-72. p.1065 left column 4th paragraphPubMed ID19043850
Comments P.1065 left column 4th paragraph: "Ceramides are amide-linked fatty acids containing a long-chain amino alcohol called sphingoid base and account for 30 to 40% of SC lipids. Ceramides are generated by serine-palmitoyl transferase as rate-limiting enzyme and by hydrolysis of both glucosylceramide (by β-glucocerebrosidase) (ref 25) and sphingomyelin (by acid sphingomyelinase) (ref 26). The SC contains at least nine different free ceramides (ref 27), two of which are ceramide A and ceramide B, covalently bound to cornified envelope proteins, most importantly to involucrin (ref 28)."
Entered by Uri M
ID 113173