Elongation rate of RNA polymerase II

Range ~3-4 kb/min
Organism Mammals
Reference Hao S, Baltimore D. RNA splicing regulates the temporal order of TNF-induced gene expression. Proc Natl Acad Sci U S A. 2013 Jul 16 110(29):11934-9. doi: 10.1073/pnas.1309990110. p.11938 left column bottom paragraphPubMed ID23812748
Primary Source Darnell JEJ, Jr. (2013) Reflections on the history of pre-mRNA processing and highlights of current knowledge: A unified picture. RNA 19(4):443–460. doi: 10.1261/rna.038596.113.PubMed ID23440351
Comments P.11938 left column bottom paragraph: "Previous studies have indicated that the elongation rate of mammalian RNA polymerase II is about 3–4 kb/min [reviewed by Darnell (primary source)]. [Investigators] found a somewhat faster rate, perhaps because [they] used different cells or different techniques. The method [they] used does not involve any perturbation of the cell by drugs whereas previous studies have often used cells recovering from inhibition by the drug DRB (5,6-dichloro-1-b-d-ribofuranosylbenzimidazole). In any case, [investigators'] estimates are not materially different from previous ones—the key point for this study is that pre-mRNA synthesis can be completed in a much shorter time than splicing is completed."
Entered by Uri M
ID 112440