Half-life of degradation of most intracellular proteins

Range ~cell doubling rate
Organism Unspecified
Reference Larance M, Ahmad Y, Kirkwood KJ, Ly T, Lamond AI. Global subcellular characterization of protein degradation using quantitative proteomics. Mol Cell Proteomics. 2013 Mar12(3):638-50. doi: 10.1074/mcp.M112.024547. p.638 left column bottom paragraphPubMed ID23242552
Comments P.638 left column bottom paragraph: "Most intracellular proteins have similar degradation rates, with a half-life approximating the cell doubling rate. Under 5% of proteins display degradation rates more than threefold faster than the proteome average (refs 3–5, 7)."
Entered by Uri M
ID 112249