pH required for de novo actin assembly in mammalian cells

Range >7.2 unitless
Organism Mammals
Reference Damaghi M, Wojtkowiak JW, Gillies RJ. pH sensing and regulation in cancer. Front Physiol. 2013 Dec 17 4 :370. doi: 10.3389/fphys.2013.00370. p.4 left column bottom paragraphPubMed ID24381558
Primary Source Webb, B. A., Chimenti, M., Jacobson, M. P., and Barber, D. L. (2011). Dysregulated pH: a perfect storm for cancer progression. Nat. Rev. Cancer 11, 671–677. doi: 10.1038/nrc3110PubMed ID21833026
Comments p.4 left column bottom paragraph:"Although the effects of pH on intracellular processes are ubiquitous, one of the major pH-sensitive systems in the cells is the actin cytoskeleton. The assembly of globular (G-actin) to filamentous (F-actin) and higher structures as well as the reverse process of filament disassembly play different roles in cancer cell processes and behaviors such as vesicle trafficking, contraction, migration, invasion, and metastasis. De novo actin assembly in mammalian cells requires pHi > 7.2 (primary source) and changes (of 0.3–0.4 units) in pHi induce dramatic differences in actin filament assemblies and architectures. These observations suggest that disruption of pHi in either direction can negatively impact the mobility of cancer cells and eventually affect metastasis (Hansen and Kwiatkowski, 2013)."
Entered by Uri M
ID 112181