Number of pre-B cells produced daily in young rats

Range 2×10^7 to 5×10^7 pre-B cells/day
Organism Rat Rattus norvegicus
Reference Macallan DC et al., B-cell kinetics in humans: rapid turnover of peripheral blood memory cells. Blood. 2005 May 1 105(9):3633-40. p.3637 right column top paragraphPubMed ID15644412
Primary Source Deenen GJ, Van Balen I, Opstelten D. In rat B lymphocyte genesis sixty percent is lost from the bone marrow at the transition of nondividing pre–B cell to sIgM B lymphocyte, the stage of Ig light chain gene expression. Eur J Immunol. 1990 20 :557-564.PubMed ID2108044
Comments p.3637 right column top paragraph:"Labeling of cells in the bone marrow that have a long postmitotic maturation period before exiting from the marrow might account for the late rise in label seen in some individuals. Estimates of the rate of production of B cells suggest that 20 to 50×10^6 pre–B cells are produced daily in young rats, enough to replace totally the peripheral B-cell pool of approximately 150 million cells in a very few days [primary source]."
Entered by Uri M
ID 111627