Number of presynaptic nerve terminals that most neurons form

Range >500 nerve terminals/neuron
Organism Unspecified
Reference Sudhof TC. The synaptic vesicle cycle. Annu Rev Neurosci. 2004 27: 509-47. p.509 bottom paragraphPubMed ID15217342
Comments "Synaptic transmission is initiated when an action potential triggers neurotransmitter release from a presynaptic nerve terminal (Katz 1969). An action potential induces the opening of Ca2+ channels, and the resulting Ca2+ transient stimulates synaptic vesicle exocytosis (Figure 1). After exocytosis, synaptic vesicles undergo endocytosis, recycle, and refill with neurotransmitters for a new round of exocytosis. Nerve terminals are secretory machines dedicated to repeated rounds of release. Most neurons form >500 presynaptic nerve terminals that are often widely separated from the neuronal cell bodies. Action potentials, initiated in the neuronal cell body, travel to all of the cell body’s nerve terminals to be transformed into synaptic secretory signals."
Entered by Uri M
ID 111276