Number of transcription complexes that are associated with each of 120–150 active rRNA genes in HeLa cell

Range 100 - 120 transcription complexes/rRNA copy
Organism Human Homo sapiens
Reference Jackson DA, Pombo A, Iborra F. The balance sheet for transcription: an analysis of nuclear RNA metabolism in mammalian cells. FASEB J. 2000 Feb14(2):242-54. p.243 left column 2nd paragraphPubMed ID10657981
Primary Source [19] Miller, O. L., Jr., and Bakken, A. H. (1972) Morphological studies of transcription. Acta Endocrinol. Suppl. 167, 155–177 [20] Jackson DA, Iborra FJ, Manders EM, Cook PR. Numbers and organization of RNA polymerases, nascent transcripts, and transcription units in HeLa nuclei. Mol Biol Cell. 1998 Jun9(6):1523-36.PubMed ID4562652 ,9614191
Comments "In a HeLa cell, 120–150 active rRNA genes (primary source 20) are each associated with 100–120 transcription complexes (primary source 19)."
Entered by Uri M
ID 111154