New acetylcholine receptors-distribution and turnover

Range Table - link
Organism Mouse Mus musculus
Reference Salpeter MM, Harris R. Distribution and turnover rate of acetylcholine receptors throughout the junction folds at a vertebrate neuromuscular junction. J Cell Biol. 1983 Jun96(6):1781-5. p.1783 table IIPubMed ID6853602
Method "[Researchers] used innervated mouse sternomastoid muscle to examine both the localization and turnover rate of junctional receptors at the top thickened pjm [post junctional membrane] and at the bottom nonthickened membrane. [Researchers] did this for the total population of receptors as well as for receptors newly inserted at the junction during a 2- d period. [They] found that the turnover rate of total and newly inserted AChRs [Acetylcholine receptors] in both the top and bottom of the pjm are within the range given by others for innervated junctional AChR. [They] further found that there is no apparent preferential localization of newly inserted receptors in the bottom vs. the top of the folds. This suggests that during turnover of adult junctional receptors there is a rapid equilibration of receptor location to maintain a steady state throughout the entire membrane."
Comments "Fig. 1 illustrates an EM [electron microscopy] autoradiogram such as was used for the analysis. Tables I and II and Fig. 2 give the receptor site densities at the thickened pjm [post junctional membrane] and the bottom folds for total receptors and for receptors newly inserted during a 2-d period. Data are also given for the degradation of these newly inserted receptors during a period of 6 d." See notes beneath table
Entered by Uri M
ID 111078