||"The large size of nuclei in higher eukaryotes might therefore further decrease the rate of mRNA export compared to cells with smaller nuclei. The probability of an mRNP to find its
way back to the periphery after bounding off the nuclear envelope
will be significantly lower in cells with a large nucleus as compared
to a yeast cell, where nuclei are small (2 µm in diameter) and an
mRNA can move across it in a few seconds. However, mRNA diffusion
behavior in yeast has not yet been measured."