Fraction of mitochondrial transcripts out of total mRNA in the heart

Value 30 %
Organism Human Homo sapiens
Reference Mercer TR et al., The human mitochondrial transcriptome. Cell. 2011 Aug 19 146(4):645-58. doi: 10.1016/j.cell.2011.06.051. p.648 left column 3rd paragraphPubMed ID21854988
Method "[Researchers] examined mitochondrial gene expression across 16 human tissues sequenced as part of the Illumina Body Tissue Atlas (Extended Experimental Procedures). [They] performed hierarchical clustering to identify tissue-specific differences (Figure 2E and Table S2B), noting some differences in mitochondrial transcript abundance in samples from human tissue and 143B cells due to the alternative use of polyadenylated or total RNA during library preparation..."
Comments "In the heart, mitochondrial transcripts comprise almost 30% of total mRNA, whereas mitochondria contribute a lower bound of 5% to the total mRNA of tissues with lower energy demands (adrenal, ovary, thyroid, prostate, testes, lung, lymph, and white blood cells)."
Entered by Uri M
ID 110504